Cold exposure-induced loss of beneficial gut bacterial sEV is associated with the pathogenesis of bone loss through pyroptosis pathway
Li-Min Lei, Xiao Lin, Feng Xu, Fu-Xing-Zi Li, Su-Kang Shan, Ming-Hui Zheng, Bei Guo, Ye-Chi Cao, Zhi-Ang Zhou, Si-Yang He, Yan-Lin Wu, Xi Chen, Fei Zhang, Wen-Hui Zhang, Jia-Qi Zhu, Ya-Rong Wang, Qi-Rong Deng, Zi-Ping He, Feng Wu, Ling-Qing Yuan, Zhi-Hong Li · 2026
Read Cold exposure-induced loss of beneficial gut bacterial sEV is associated with the pathogenesis of bone loss through pyroptosis pathway by Li-Min Lei, Xiao Lin, Feng Xu, Fu-Xing-Zi Li, Su-Kang Shan, Ming-Hui Zheng, Bei Guo, Ye-Chi Cao, Zhi-Ang Zhou, Si-Yang He, Yan-Lin Wu, Xi Chen, Fei Zhang, Wen-Hui Zhang, Jia-Qi Zhu, Ya-Rong Wang, Qi-Rong Deng, Zi-Ping He, Feng Wu, Ling-Qing Yuan, Zhi-Hong Li (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13548517.txt.
Description
Li-Min Lei and a large research team examine how cold exposure damages bone through changes in gut bacteria, in a 2026 mouse study. Earlier work had linked cold conditions to bone loss, and the gut is known to influence bone health. The authors asked whether bacteria living at room temperature could protect animals kept in the cold, and which microbe mattered most.
Mice housed with room-temperature partners, or given their gut microbes, kept more bone than mice exposed to cold alone. Sequencing pointed to one species, Bifidobacterium pseudolongum, whose numbers fell in the cold and recovered with co-housing. Giving that bacterium by mouth eased the bone loss. Tiny vesicles released by the bacterium reached bone tissue, supported bone formation, and calmed a cell-death pathway in marrow stromal cells.
Catalog record
| CREATOR | Li-Min Lei, Xiao Lin, Feng Xu, Fu-Xing-Zi Li, Su-Kang Shan, Ming-Hui Zheng, Bei Guo, Ye-Chi Cao, Zhi-Ang Zhou, Si-Yang He, Yan-Lin Wu, Xi Chen, Fei Zhang, Wen-Hui Zhang, Jia-Qi Zhu, Ya-Rong Wang, Qi-Rong Deng, Zi-Ping He, Feng Wu, Ling-Qing Yuan, Zhi-Hong Li |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 82572 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |