Dynamic immune state transitions and metastatic niche remodelling drive osteosarcoma evolution as a barrier-restricted immune-cold ecosystem
Jiangyou Shi, Rongchun Chen · 2026
Read Dynamic immune state transitions and metastatic niche remodelling drive osteosarcoma evolution as a barrier-restricted immune-cold ecosystem by Jiangyou Shi, Rongchun Chen (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13548505.txt.
Description
Jiangyou Shi and Rongchun Chen reframe osteosarcoma, a bone cancer, as an immune ecosystem that changes over time and place. Their 2026 review argues that calling the tumor simply immune-cold, unresponsive to immune drugs, misses how its defenses shift. Lung spread sites get special attention.
Evidence from single-cell and tissue studies shows varied immune layouts in first tumors, treated tumors, and lung deposits. In the lungs, helper and suppressor cells plus scar-like tissue build a sheltered niche that resists therapy. The authors propose sorting patients by immune state rather than piling on treatments. They also urge trials fitted to the lung niche and biomarkers that map where immune cells actually sit.
Catalog record
| CREATOR | Jiangyou Shi, Rongchun Chen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 68 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |