Functional and Proteomic Profiles of CD3(+) Plasma‐Derived Small Extracellular Vesicles Differentiate Cancer Patients From Healthy Donors
Piotr Widlak, Jie Han, Alicja Gluszko, Justyna Mika, Aneta Zebrowska, Sujan Kumar Mondal, Marta Gawin, Yana G Najjar, Joanna Polańska, Monika Pietrowska, Theresa L Whiteside · 2026
Read Functional and Proteomic Profiles of CD3(+) Plasma‐Derived Small Extracellular Vesicles Differentiate Cancer Patients From Healthy Donors by Piotr Widlak, Jie Han, Alicja Gluszko, Justyna Mika, Aneta Zebrowska, Sujan Kumar Mondal, Marta Gawin, Yana G Najjar, Joanna Polańska, Monika Pietrowska, Theresa L Whiteside (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13548450.txt.
Description
Eleven researchers profile tiny vesicles shed by T cells in melanoma patients in a paper from 2026. Vesicles were fished from blood plasma using a T cell marker. Those from patients behaved differently from healthy donors' vesicles in cell tests. Patient vesicles slowed T cell growth yet stimulated a melanoma cell line. Protein profiling found hundreds of vesicle proteins, most shared with parent T cells.
Sixty-six proteins separated patients from donors. The raised ones clustered in cancer-linked signaling pathways. Tumor vesicles seem to rewire T cells to release look-alike parcels. The authors propose these vesicles as a liquid biopsy of a patient's T cells. Functional and protein evidence agree.
Catalog record
| CREATOR | Piotr Widlak, Jie Han, Alicja Gluszko, Justyna Mika, Aneta Zebrowska, Sujan Kumar Mondal, Marta Gawin, Yana G Najjar, Joanna Polańska, Monika Pietrowska, Theresa L Whiteside |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 62 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |