GTPase RAB31 supports ANXA1-driven macrophage education through clathrin-mediated endocytosis to suppress antitumor immunity
Jingjing Liu, Shanshan Wang, Dengyi Bao, Ge Dong, Yunxi Ma, Guorong Zhang, Xin Liu, Dongli Zhang, Lulu Wang, Shuqian Xu, Zhigang Cai · 2026
Read GTPase RAB31 supports ANXA1-driven macrophage education through clathrin-mediated endocytosis to suppress antitumor immunity by Jingjing Liu, Shanshan Wang, Dengyi Bao, Ge Dong, Yunxi Ma, Guorong Zhang, Xin Liu, Dongli Zhang, Lulu Wang, Shuqian Xu, Zhigang Cai (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13548287.txt.
Description
A cell-traffic protein helps tumors teach immune cells to stand down, and a 2026 study by Jingjing Liu and co-authors maps that lesson. The protein, RAB31, is common in immune cells called macrophages, which tumors often bend toward helping the cancer instead of fighting it.
The team profiled the protein across human cancers with single-cell data and stained samples, then knocked it out in mice with tumors. Deep profiling of the tumor setting followed, along with bone marrow swaps and cell transfers to find which cells matter. Lab work traced how RAB31 uses a standard intake route to handle a partner signal, ANXA1. The findings name a traffic step that shapes anti-tumor immunity.
Catalog record
| CREATOR | Jingjing Liu, Shanshan Wang, Dengyi Bao, Ge Dong, Yunxi Ma, Guorong Zhang, Xin Liu, Dongli Zhang, Lulu Wang, Shuqian Xu, Zhigang Cai |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 74 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |