Dual function of transforming growth factor beta 2 in the progression of gastric carcinoma
Daiki Imanishi, Hinano Nishikubo, Dongheng Ma, Tomoya Sano, Canfeng Fan, Takashi Sakuma, Masakazu Yashiro · 2026
Read Dual function of transforming growth factor beta 2 in the progression of gastric carcinoma by Daiki Imanishi, Hinano Nishikubo, Dongheng Ma, Tomoya Sano, Canfeng Fan, Takashi Sakuma, Masakazu Yashiro (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13548160.txt.
Description
Daiki Imanishi and co-authors examine, in a 2026 study, a growth signal with two different roles in gastric carcinoma, or stomach cancer. The signal is transforming growth factor beta 2, known as TGF beta 2. It is produced by cancer cells and by the stromal cells around them, including fibroblasts. Two related signals are well studied in this cancer, but the role of TGF beta 2 was unclear.
The team stained 518 tumor specimens and scored the signal separately in cancer cells and in cancer-associated fibroblasts. High levels in cancer cells were linked to deeper tumor growth and later stage, but not to invasion of vessels. High levels in the fibroblasts were linked to spread through vessels instead. Patients with high levels in cancer cells but low levels in fibroblasts had the worst five-year outlook. The authors conclude that the effect of the signal depends on where it is expressed.
Catalog record
| CREATOR | Daiki Imanishi, Hinano Nishikubo, Dongheng Ma, Tomoya Sano, Canfeng Fan, Takashi Sakuma, Masakazu Yashiro |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 20 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |