ATP Release and Purinergic Signaling Potentiate β‐Adrenergic Effects on Brown Adipocytes
Marco Tozzi, Emilie B. Berggreen, Rui Zhang, Anders Gudiksen, Wei Li, Mathias B. Matz, Henriette Pilegaard, Jacob B. Hansen, Ivana Novak · 2026
Read ATP Release and Purinergic Signaling Potentiate β‐Adrenergic Effects on Brown Adipocytes by Marco Tozzi, Emilie B. Berggreen, Rui Zhang, Anders Gudiksen, Wei Li, Mathias B. Matz, Henriette Pilegaard, Jacob B. Hansen, Ivana Novak (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13548067.txt.
Description
Marco Tozzi and colleagues showed that brown fat cells release the energy molecule ATP when adrenaline-like signals switch them into heat-making mode. The released ATP then amplifies the very signals that freed it. Brown fat burns fuel to produce heat in the cold. Working with cultured brown fat cells and mouse tissue, the team tracked ATP release in real time and measured oxygen use, sugar breakdown, and fat splitting.
Release ran through a channel protein called pannexin-1 under control of the cell's main adrenaline relay. Glucose raised release while insulin trimmed it. Blocking the channel or mopping up outside ATP weakened the fat-burning responses, and both ATP and adrenaline raised calcium signals on different schedules. Cold exposure reshaped the tissue's ATP receptor mix.
Catalog record
| CREATOR | Marco Tozzi, Emilie B. Berggreen, Rui Zhang, Anders Gudiksen, Wei Li, Mathias B. Matz, Henriette Pilegaard, Jacob B. Hansen, Ivana Novak |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |