Dynamic chromatin tethering of MDC1 regulates genome stability
Joshua R Heyza, Mariia Mikhova, Cody Phillips, Shomaila Mehmood, Gloria I Perez, David G Broadbent, Jens C Schmidt · 2026
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Description
Joshua Heyza and co-authors show how a repair protein holds broken DNA together in a 2026 study. Breaks that cut both DNA strands are among the most toxic cell injuries. One repair path copies the lost span from a matching template, but the ends must stay close.
The protein, MDC1, has a repeat-rich tail that can grip the DNA packaging at many points. That grip alone can tether loose chromatin in tests. In resting cells the grip loads a second repair protein and speeds the copy path. During cell division, a chemical tag loosens the grip so chromosomes do not stick wrongly. A partner complex keeps some tethering in place. The work ties grip strength to genome safety.
Catalog record
| CREATOR | Joshua R Heyza, Mariia Mikhova, Cody Phillips, Shomaila Mehmood, Gloria I Perez, David G Broadbent, Jens C Schmidt |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 81 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |