The aspiration of precision glucocorticoid pharmacotherapy in immune-mediated diseases: where do we stand in integrating pharmacogenomics and biomarkers for individualized treatment?
Matteo Colina, Gabriele Campana · 2026
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Description
Matteo Colina and Gabriele Campana review the push for personalized steroid dosing in a 2026 paper. Glucocorticoids calm immune disease worldwide, yet patients vary hugely in benefit and harm, and prescribing still runs on habit. The review gathers precision attempts across three fronts: genes, drug levels, and disease markers.
Gene variants in the hormone's receptor, its chaperones, and its breakdown paths show hints of steering response, though none yet earns a place in clinic rules. Model-guided dosing from blood levels is the second front. Disease-specific markers form the third, spanning lung, joint, gut, and critical care. The authors judge the field promising but not yet practice-changing, and map what proof is still missing.
Catalog record
| CREATOR | Matteo Colina, Gabriele Campana |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 83 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |