Association Between Mutation Context–Associated RUNX1 Transcriptional States and Immune–Stromal Heterogeneity in Nonsmall Cell Lung Cancer
Jinyao Wang, Shuang Li, Jingjing Zhou, Jing Yang, Huan Ma · 2026
Read Association Between Mutation Context–Associated RUNX1 Transcriptional States and Immune–Stromal Heterogeneity in Nonsmall Cell Lung Cancer by Jinyao Wang, Shuang Li, Jingjing Zhou, Jing Yang, Huan Ma (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13547596.txt.
Description
Jinyao Wang, Shuang Li, Jingjing Zhou, Jing Yang, and Huan Ma study a gene regulator in lung cancer in the light of each tumor's mutation mix. Their paper is from two thousand twenty-six. This cancer type is highly varied, both in its driver mutations and in the immune cells around the tumor. How those two sides connect is still unclear.
The team merged mutation, gene activity, and clinical data from large public cohorts. They tracked a regulator called RUNX1 across six common driver mutations. Rather than being a driver itself, RUNX1 marked a state that varied by mutation context. Its activity was then mapped against immune and support-cell traits in the tumor. Single-cell and spatial data showed where RUNX1 sits in the tissue. The work links gene context to the tumor's local environment.
Catalog record
| CREATOR | Jinyao Wang, Shuang Li, Jingjing Zhou, Jing Yang, Huan Ma |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 82 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |