Metabolic pathway signatures define prognostic subtypes of lung adenocarcinoma
Doris Kafita, Zitha Mukwamba, Vanity Mapulanga, Adon Chawe, Musalula Sinkala · 2026
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Description
Doris Kafita and colleagues sorted 510 lung adenocarcinoma tumors in 2026 by how their metabolism genes behave, finding two subtypes with sharply different outlooks. Metabolic rewiring is a hallmark of cancer, yet its link to this cancer's uneven course was unclear. Unsupervised clustering of the tumors' metabolic profiles produced the split.
Patients in the first subtype lived significantly longer. Their tumors favored breaking down choline, a membrane nutrient. The aggressive second subtype instead ran its central carbon machinery hot, including the citric acid cycle and the respiratory chain. One enzyme from that cycle stood out as the strongest single predictor of higher risk, while a sugar-processing enzyme predicted lower risk. The authors offer the subtypes as a prognosis framework and a map of metabolic weak points.
Catalog record
| CREATOR | Doris Kafita, Zitha Mukwamba, Vanity Mapulanga, Adon Chawe, Musalula Sinkala |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39604 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |