A CD14‐Targeting In Situ Hydrogel Directs Macrophage Reprogramming to Minimize Scar Formation
Rui Fang, Simeng Chen, Qiaozhen Liu, Wenwen Ni, Xi Xu, Jianfa Zhang · 2026
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Description
Rui Fang, Simeng Chen, Qiaozhen Liu, Wenwen Ni, Xi Xu, and Jianfa Zhang present a wound gel that aims to cut scarring. Their 2026 paper starts from a gap: most dressings sit passive and do not steer repair. Their powder, made from a microbial sugar chain, gels on contact with wound fluid or blood. It sticks to tissue and is gentle on cells.
In mouse burns, rabbit ear scars, and rat cuts, the gel sped closure and cut scar build-up. Hair, vessels, and nerves regrew better as well. Tests showed the gel binds a receptor on immune cells called CD14. That binding re-tunes those cells, calms a key signal path, and shifts signals that drive vessel growth and fibrosis.
Catalog record
| CREATOR | Rui Fang, Simeng Chen, Qiaozhen Liu, Wenwen Ni, Xi Xu, Jianfa Zhang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 62 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |