Bacterial polar metabolites modulate β-amyloid toxicity and cholinergic dysfunction in models of Alzheimer’s disease
Ana Carolina Costa Santos, Joberth Lee Corrêa, Rener Mateus Francisco Duarte, Serena Mares Malta, Tamiris Sabrina Rodrigues, Débora de Oliveira Santos, Paulo Rogério de Faria, Fernanda Naves Araújo do Prado Mascarenhas, Renata Graciele Zanon, Nadla Soares Cassemiro, Carlos Alexandre Carollo, Foued S · 2026
Read Bacterial polar metabolites modulate β-amyloid toxicity and cholinergic dysfunction in models of Alzheimer’s disease by Ana Carolina Costa Santos, Joberth Lee Corrêa, Rener Mateus Francisco Duarte, Serena Mares Malta, Tamiris Sabrina Rodrigues, Débora de Oliveira Santos, Paulo Rogério de Faria, Fernanda Naves Araújo do Prado Mascarenhas, Renata Graciele Zanon, Nadla Soares Cassemiro, Carlos Alexandre Carollo, Foued S (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13547416.txt.
Description
Ana Carolina Costa Santos and colleagues tested whether compounds produced by a bacterium can soften the toxicity of amyloid-beta, the protein that accumulates in Alzheimer's disease. A bioactivity-guided search isolated an aqueous fraction rich in polar metabolites. The fraction scored high on three antioxidant assays. Fruit flies engineered to express human amyloid accumulated less of it and showed milder brain tissue damage when treated. Human neuronal cultures exposed to aggregated amyloid survived better with treatment given afterward.
The fraction also blocked two enzymes whose failure weakens cholinergic signaling in Alzheimer's. Genome sequencing identified the source bacterium. Benefit appeared under therapeutic rather than preventive timing in cell culture, an honest limit the authors report. The twenty twenty-six study adds gut-brain-axis chemistry to the list of places Alzheimer drug hunters are looking.
Catalog record
| CREATOR | Ana Carolina Costa Santos, Joberth Lee Corrêa, Rener Mateus Francisco Duarte, Serena Mares Malta, Tamiris Sabrina Rodrigues, Débora de Oliveira Santos, Paulo Rogério de Faria, Fernanda Naves Araújo do Prado Mascarenhas, Renata Graciele Zanon, Nadla Soares Cassemiro, Carlos Alexandre Carollo, Foued S |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |