Adipocyte caspase-8 but not RIPK3 promotes adiposity
Carmen K Chan, Rukhsana Aslam, Fan Yang, Arshdeep Panesar, Anne Hakem, Razqallah Hakem, Herbert Y Gaisano, Daniel A Winer, Cynthia T Luk · 2026
Read Adipocyte caspase-8 but not RIPK3 promotes adiposity by Carmen K Chan, Rukhsana Aslam, Fan Yang, Arshdeep Panesar, Anne Hakem, Razqallah Hakem, Herbert Y Gaisano, Daniel A Winer, Cynthia T Luk (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13547226.txt.
Description
Carmen K Chan and colleagues used engineered mice in 2026 to test whether a form of inflammatory cell death in fat cells drives obesity. Necroptosis, the death mode in question, runs through a protein called RIPK3, which was switched on in the fat of obese mice and tracked with body mass in human fat samples. The team deleted either RIPK3's activation piece or caspase-8, a second death regulator, specifically in fat cells.
Removing caspase-8 from fat cells made mice leaner, yet deleting RIPK3 alongside it erased that protection, and removing only the RIPK3 activation piece changed nothing about weight or blood sugar. Cell experiments suggested caspase-8 supports fat cell formation directly. The authors conclude the caspase matters for building fat, not mainly through the necroptosis route.
Catalog record
| CREATOR | Carmen K Chan, Rukhsana Aslam, Fan Yang, Arshdeep Panesar, Anne Hakem, Razqallah Hakem, Herbert Y Gaisano, Daniel A Winer, Cynthia T Luk |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56444 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |