Biotransformation of common NSAIDs by Cunninghamella species and resulting metabolite toxicity
Aleksandra Pietrzak, Barbara Dąbrówka, Justyna Popiół-Adamska, Agnieszka Gunia-Krzyżak, Dorota Żelaszczyk, Paulina Koczurkiewicz-Adamczyk, Kamil Piska, Paweł Żmudzki, Elżbieta Pękala, Karolina Słoczyńska · 2026
Read Biotransformation of common NSAIDs by Cunninghamella species and resulting metabolite toxicity by Aleksandra Pietrzak, Barbara Dąbrówka, Justyna Popiół-Adamska, Agnieszka Gunia-Krzyżak, Dorota Żelaszczyk, Paulina Koczurkiewicz-Adamczyk, Kamil Piska, Paweł Żmudzki, Elżbieta Pękala, Karolina Słoczyńska (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13547222.txt.
Description
Aleksandra Pietrzak and a large team tested in 2026 whether Cunninghamella fungi can break down three common painkillers that pollute water, and whether the leftovers are any safer. The fungi efficiently transformed diclofenac and ibuprofen into several breakdown products, while ketoprofen barely changed. The treated mixtures then went through a battery of toxicity tests, from bacterial light assays and algae growth to human and rat cell lines.
Fungal treatment lowered the water toxicity of both transformed drugs, and cell tests showed the products harmed liver, nerve, and heart cells less than the original compounds. No sample caused mutations in the standard bacterial test. Hormone-like interference mostly vanished, though a faint estrogen-like activity appeared. The authors back fungal treatment with careful product checking.
Catalog record
| CREATOR | Aleksandra Pietrzak, Barbara Dąbrówka, Justyna Popiół-Adamska, Agnieszka Gunia-Krzyżak, Dorota Żelaszczyk, Paulina Koczurkiewicz-Adamczyk, Kamil Piska, Paweł Żmudzki, Elżbieta Pękala, Karolina Słoczyńska |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 68362 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |