CDK1-mediated phosphorylation of EPLIN is crucial for mitotic spindle positioning
Jia-Rong Fan, Yun Hsieh, Chien-Chen Lai, Hong-Chen Chen · 2026
Read CDK1-mediated phosphorylation of EPLIN is crucial for mitotic spindle positioning by Jia-Rong Fan, Yun Hsieh, Chien-Chen Lai, Hong-Chen Chen (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13547218.txt.
Description
Fan, Hsieh, Lai, and Chen trace how a dividing cell keeps its spindle centered. Their 2026 paper studies the protein EPLIN during mitosis. The spindle must anchor to the cell cortex correctly. Misplaced spindles risk uneven chromosome separation and cancer. EPLIN bundles actin, the protein forming the cell's inner shell.
Removing EPLIN made spindles drift off position in experiments. Cells stalled in metaphase with blebbing, abnormal surface bulges. The kinase CDK1 tags EPLIN at one key site, Ser203. That tag proved essential for correct spindle placement. Tagged EPLIN reshapes branched actin filaments into star-like arrays. It also traps loose actin bundles and the Arp2/3 complex. Excess new actin growth near the cortex is thereby prevented. The cortex stays orderly while division proceeds. Without the tag, cortical actin piles up abnormally. The work names a concrete control point for division fidelity. It links one phosphorylation event to whole-cell geometry.
Catalog record
| CREATOR | Jia-Rong Fan, Yun Hsieh, Chien-Chen Lai, Hong-Chen Chen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 75 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |