GRP78 in viral pneumonia: dual regulatory mechanisms and translational prospects
Hang Ruan, Qian-Rui Huang, Li-Juan Zou, Shu-Sheng Li · 2026
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Description
Hang Ruan and co-authors reviewed in 2026 the double-edged role of GRP78, a helper protein that manages stressed cells, in viral pneumonia caused by influenza, RSV, and coronaviruses. Where the protein sits in the cell changes what it does. On the cell surface it helps viruses attach and enter, while inside the cell's protein factory it supports viral copying and can worsen lung inflammation.
The same protein also protects lung tissue by limiting cell death and calming overload in that factory. Drug strategies under study include small molecules that block it, larger biological drugs, indirect regulators, and natural products. The authors map these approaches and their early evidence, aiming to guide precise treatments that blunt the viral help without losing the protection.
Catalog record
| CREATOR | Hang Ruan, Qian-Rui Huang, Li-Juan Zou, Shu-Sheng Li |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 65362 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |