A Shared EGR1–IL-32–Macrophage Polarisation Signature in Rheumatoid Arthritis and Metabolic Dysfunction-Associated Steatotic Liver Disease
Lijun Pang, Yunfei Li, Lili Cheng, Chuanbing Huang · 2026
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Description
Pang, Li, Cheng, and Huang study shared traits of rheumatoid arthritis and fatty liver disease in twenty twenty-six. The two conditions often occur together in the same patient. Their shared molecular features were not well defined. The team combined population data, hospital records, gene data, and lab tests.
In national survey data, the link between the diseases faded after full adjustment. In a hospital cohort, patients with both diseases had higher activity and liver injury scores. Gene analyses across diseases found six shared genes with consistent changes. One gene, EGR1, fell stepwise from healthy people to those with both diseases. A related protein, IL-32, rose across the same groups. Macrophage patterns shifted toward an inflammatory type. The authors propose a shared signature for the combined condition.
Catalog record
| CREATOR | Lijun Pang, Yunfei Li, Lili Cheng, Chuanbing Huang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 82 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |