Nanomedicine-Empowered CAR-T Therapy for Multiple Myeloma: Toward Programmable, Durable, and Precision Immunotherapy
Can Huang, Xuyan Zhang, Yuanyin Teng, Zhongsong Zhang, Bing Wang, Panpan Gu, Xiang Deng, Dianwen Wang, Hongli Xiao, Lingli Zou, Meng Zhao, Caifeng Zheng, Gaochun Zeng, Jianyun Li, Zoufang Huang · 2026
Read Nanomedicine-Empowered CAR-T Therapy for Multiple Myeloma: Toward Programmable, Durable, and Precision Immunotherapy by Can Huang, Xuyan Zhang, Yuanyin Teng, Zhongsong Zhang, Bing Wang, Panpan Gu, Xiang Deng, Dianwen Wang, Hongli Xiao, Lingli Zou, Meng Zhao, Caifeng Zheng, Gaochun Zeng, Jianyun Li, Zoufang Huang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13546692.txt.
Description
CAR-T cell therapy has transformed care for multiple myeloma, a blood cancer that still usually returns. Can Huang and co-authors review in 2026 why the engineered cells lose their grip. The tumor remodels its target antigen, the cells exhaust, their metabolism falters, and the bone marrow niche shields the cancer. Nanomedicine, they argue, might answer each failure.
Tiny carriers could speed up cell manufacturing, or even build CAR-T cells inside the body. Others could tune antigen density on tumor cells, remodel the hostile marrow niche, and track relapse risk as it changes. The review weaves tumor immunology, materials science, and blood-cancer medicine into a program: programmable, durable, precise immunotherapy. The authors are candid that translation — making these platforms safe, fast, and affordable — is the hard part ahead.
Catalog record
| CREATOR | Can Huang, Xuyan Zhang, Yuanyin Teng, Zhongsong Zhang, Bing Wang, Panpan Gu, Xiang Deng, Dianwen Wang, Hongli Xiao, Lingli Zou, Meng Zhao, Caifeng Zheng, Gaochun Zeng, Jianyun Li, Zoufang Huang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 216 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |