Identification of JAML as an Immune-Associated Prognostic Marker in Non-Small Cell Lung Cancer
Qin Tian, Fucheng Zhang, Chunyan Han · 2026
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Description
Qin Tian, Fucheng Zhang, and Chunyan Han nominate, in a 2026 study, a little-studied adhesion protein as a prognostic marker in the commonest form of lung cancer. The protein, JAML, helps white blood cells stick, move, and activate, yet its behavior in non-small cell lung cancer was unmapped. The team read its levels across large public tumor data sets, checked survival against them, and verified the pattern in fresh tissue pairs.
The protein runs low in tumors, lowest in the squamous subtype, and patients whose tumors kept more of it lived significantly longer. Its levels also tracked the crowd of immune cells inside the tumor, most strongly the killer T cells. Bench checks confirmed that healthy neighboring tissue carries over twice the tumor's amount. The authors propose JAML as a marker of outlook and a signpost to how this cancer manages its immune neighborhood.
Catalog record
| CREATOR | Qin Tian, Fucheng Zhang, Chunyan Han |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |