Prognostic Value of VPS45 in HCC and Its Correlation with Immune Microenvironment
Jiming Duan, Wenjun Zhao, Na Lv, Changhu Xie, Guoping Zhang, Lei Zhang, Renhou Zhi · 2026
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Description
Jiming Duan and six co-authors size up a cell-sorting protein as a liver cancer marker in a 2026 study. VPS45 ferries cargo inside cells, and hints tied it to tumors, but its story in liver cancer was unwritten.
Mining public tumor databases, the team found VPS45 switched on far higher in liver cancers, with high levels tracking worse survival. Its level also tracked which immune cells crowd the tumor, and computer scores hinted at how patients might answer immune therapy. In dish-grown liver cancer cells, lab assays probed what the protein does to growth and spread. The authors pitch VPS45 as both a warning flag and a possible target.
Catalog record
| CREATOR | Jiming Duan, Wenjun Zhao, Na Lv, Changhu Xie, Guoping Zhang, Lei Zhang, Renhou Zhi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |