Trajectory identification of high-risk subgroups after colorectal cancer surgery in patients with minimal residual disease: a single-center longitudinal study
Yahan Zhang, Lei Liang, Ruize Zhou, Shirong Wu, Yicheng Zhou, Jinjin Luo, Yujian Zeng, Ning Xu, Zhengqi Wen · 2026
Read Trajectory identification of high-risk subgroups after colorectal cancer surgery in patients with minimal residual disease: a single-center longitudinal study by Yahan Zhang, Lei Liang, Ruize Zhou, Shirong Wu, Yicheng Zhou, Jinjin Luo, Yujian Zeng, Ning Xu, Zhengqi Wen (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13546584.txt.
Description
Zhang and co-authors track cancer DNA in the blood, in this 2026 longitudinal study. They followed 124 patients with stage II to III colorectal cancer. All were treated at a Kunming hospital between 2017 and 2024. A single negative test for minimal residual disease, tumor DNA shed into blood after surgery, usually reassures, yet some negative patients still relapse. The team followed test trajectories over time rather than single readings.
Postoperative test positivity ran at 29.03 percent, 36 of 124 patients, and status independently predicted both progression-free and overall survival. The trajectory told the deeper story. In patients who relapsed, circulating tumor DNA signals kept climbing. In non-relapsing patients they faded or vanished. Total mutation signal was highest in the positive-and-relapsed group. Standard blood markers added further risk information. The authors conclude that watching the trend beats any single snapshot and propose a three-dimensional scoring framework for it.
Catalog record
| CREATOR | Yahan Zhang, Lei Liang, Ruize Zhou, Shirong Wu, Yicheng Zhou, Jinjin Luo, Yujian Zeng, Ning Xu, Zhengqi Wen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |