MNAT1 in gastrointestinal cancers: mechanistic insights and therapeutic strategies—a narrative review
Yanhua Zhang, Aiqi Hu, Chun Wen, Xi Yang, Xiaopai Wang, Sanping Zheng · 2026
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Description
Yanhua Zhang and co-authors reviewed in 2026 the protein MNAT1 and its possible role across gastrointestinal cancers. MNAT1 is a scaffolding piece of a kinase complex that switches on the engines of cell division and also helps drive gene transcription in growing cells. Evidence links higher activity of this complex to tumor growth in cancers of the gut, liver, stomach, and pancreas.
Drugs that block the complex's kinase, or that break the complex apart, can halt division and quiet the transcription programs tumors depend on in laboratory studies. Combinations with other treatments have also shown early promise. The authors weigh MNAT1 as a marker of outlook and treatment response, while noting the challenges of turning the biology into safe medicines.
Catalog record
| CREATOR | Yanhua Zhang, Aiqi Hu, Chun Wen, Xi Yang, Xiaopai Wang, Sanping Zheng |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37767 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |