Establishment of a chemoradio-resistance colorectal cancer cell model and its changes in biological behavior
Shan Liu, Zeng Zhang, Qian An, Yue Jia, Qin Su, Dezhi Zhu, Likun Luan, Hongying Yang, Zhirui Chuan, Xinyuan Liu, Siyu Wang, Yanyan Liu, Fenglian Fu, Qiong Sun, Luyao Ma, Juanrong Yang, Yiming Zhang, Mingzhi Duan, Peijun Yao, Changqing Yang, Yiming Xing, Hongmei Shen, Yongxin Jiang · 2026
Read Establishment of a chemoradio-resistance colorectal cancer cell model and its changes in biological behavior by Shan Liu, Zeng Zhang, Qian An, Yue Jia, Qin Su, Dezhi Zhu, Likun Luan, Hongying Yang, Zhirui Chuan, Xinyuan Liu, Siyu Wang, Yanyan Liu, Fenglian Fu, Qiong Sun, Luyao Ma, Juanrong Yang, Yiming Zhang, Mingzhi Duan, Peijun Yao, Changqing Yang, Yiming Xing, Hongmei Shen, Yongxin Jiang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13546525.txt.
Description
Shan Liu and a large team set out in 2026 to create a laboratory model of colorectal cancer that resists both chemotherapy and radiation, a major reason treatment fails. They exposed two human colon cancer cell lines to repeated high-dose treatment, mimicking intensive clinical therapy, until resistant versions emerged. The surviving cells were then compared with their parent lines in dishes and in mice.
The resistant cells grew faster, formed more colonies, and invaded and migrated more strongly than the originals. In mice they produced tumors more readily and spread more often to liver and lung. The authors offer the model as a platform for studying how resistance develops and for testing ways to reverse it.
Catalog record
| CREATOR | Shan Liu, Zeng Zhang, Qian An, Yue Jia, Qin Su, Dezhi Zhu, Likun Luan, Hongying Yang, Zhirui Chuan, Xinyuan Liu, Siyu Wang, Yanyan Liu, Fenglian Fu, Qiong Sun, Luyao Ma, Juanrong Yang, Yiming Zhang, Mingzhi Duan, Peijun Yao, Changqing Yang, Yiming Xing, Hongmei Shen, Yongxin Jiang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48088 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |