Dual-engineered extracellular vesicles enabling endothelial targeting and EphrinB2 delivery for pulp revascularization
Anqi Liu, Mengying Li, Peiyu Tang, Weiwen Ge, Zhengliang Han, Yige Dai, Lei Zhang, Changyong Yuan, Lei Qi · 2026
Read Dual-engineered extracellular vesicles enabling endothelial targeting and EphrinB2 delivery for pulp revascularization by Anqi Liu, Mengying Li, Peiyu Tang, Weiwen Ge, Zhengliang Han, Yige Dai, Lei Zhang, Changyong Yuan, Lei Qi (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13546514.txt.
Description
Anqi Liu and co-authors engineered in 2026 tiny packages called extracellular vesicles to regrow blood vessels inside damaged tooth pulp. Restoring a blood supply is the hard part of regenerating pulp, the living tissue at a tooth's center. Their vesicles carried a vessel-promoting protein, EphrinB2, and wore a DNA tag that homes to the cells lining blood vessels.
In cell tests, the targeted vesicles boosted vessel cell growth, movement, and tube formation more than untargeted ones, working through a known signaling route. Packed into a soft gel and placed in root canals, they released slowly and, after transplant in mice, supported well-vascularized pulp-like tissue. The work lays groundwork for treatments that rebuild living teeth rather than simply filling them.
Catalog record
| CREATOR | Anqi Liu, Mengying Li, Peiyu Tang, Weiwen Ge, Zhengliang Han, Yige Dai, Lei Zhang, Changyong Yuan, Lei Qi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 69852 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |