Leptin attenuates heat stress-induced mitoxyperilysis in porcine Sertoli cells by suppressing the mtDNA-cGAS-STING axis
Ming Guo, Jinyang Zhang, Shanshan Gu, Yawen Gao, Zhendong Zhu, Tao Zhang, Hongzhao Lu, Jun Luo, Wenxian Zeng · 2026
Read Leptin attenuates heat stress-induced mitoxyperilysis in porcine Sertoli cells by suppressing the mtDNA-cGAS-STING axis by Ming Guo, Jinyang Zhang, Shanshan Gu, Yawen Gao, Zhendong Zhu, Tao Zhang, Hongzhao Lu, Jun Luo, Wenxian Zeng (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13546511.txt.
Description
Ming Guo and co-authors study heat harm in pig cells that guard sperm-making, in work from 2026. Making sperm is very heat-shy, and these guard cells shield the process. The team asked if heat triggers a named cell-death path in them, and if a body hormone can block it.
Heat did set off the path, they report. It harmed the cells' power parts, leaked their DNA into the cell body, and woke alarm signals that drove swelling and death. The hormone leptin, named in the title, eased the harm by quieting that alarm chain. Findings in pig cells matter for farm breeding, where heat waves cut male fertility. They may also hint at how heat harms the same cells in other mammals.
Catalog record
| CREATOR | Ming Guo, Jinyang Zhang, Shanshan Gu, Yawen Gao, Zhendong Zhu, Tao Zhang, Hongzhao Lu, Jun Luo, Wenxian Zeng |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 55 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |