The impact for causal associations between common diseases and inflammatory bowel disease: a disease-wide bidirectional Mendelian randomization study
Yuxuan Sun, Zixin Liang, Zehua Ou, Lei Gao, Yong-Fei Wang, Jinqiu Yuan, Guangjun Yu, Rui Sun · 2026
Read The impact for causal associations between common diseases and inflammatory bowel disease: a disease-wide bidirectional Mendelian randomization study by Yuxuan Sun, Zixin Liang, Zehua Ou, Lei Gao, Yong-Fei Wang, Jinqiu Yuan, Guangjun Yu, Rui Sun (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13546168.txt.
Description
Yuxuan Sun and co-authors scan for causal links between more than a hundred common diseases and inflammatory bowel disease, in both directions. Gut inflammation in Crohn's disease and ulcerative colitis often travels with other conditions, but ordinary observation studies cannot tell cause from coincidence. The team uses Mendelian randomization, which reads gene variants as natural experiments.
Dozens of diseases showed causal ties to bowel disease or its two main forms, and childhood asthma behaved differently from adult asthma across the two gut conditions. Running the analysis backwards linked bowel disease traits to fifteen other diseases, including multiple sclerosis. A second gene-level method flagged two genes shared across conditions, pointing to common immune pathways. The catalog may guide both prevention research and drug hunting.
Catalog record
| CREATOR | Yuxuan Sun, Zixin Liang, Zehua Ou, Lei Gao, Yong-Fei Wang, Jinqiu Yuan, Guangjun Yu, Rui Sun |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |