Effectiveness and Safety of Venlafaxine in Japanese Major Depressive Disorder Patients with or without Anxious Distress (EXPAND Study): A 12-Week Prospective Observational Study
Hitoshi Sakurai, Keisuke Nomoto, Tomoki Ito, Yasuyuki Matsumoto, Shingo Higa · 2026
Read Effectiveness and Safety of Venlafaxine in Japanese Major Depressive Disorder Patients with or without Anxious Distress (EXPAND Study): A 12-Week Prospective Observational Study by Hitoshi Sakurai, Keisuke Nomoto, Tomoki Ito, Yasuyuki Matsumoto, Shingo Higa (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13546067.txt.
Description
Hitoshi Sakurai and co-authors report the EXPAND study, which followed Japanese patients starting the drug venlafaxine for major depression. The study ran for twelve weeks in routine clinics rather than a strict trial setting. About half of the patients also had anxious distress, a state of worry and tension added to low mood.
Doctors tracked a standard rating scale for depression from the start to week twelve. Scores fell in the full group and in patients with and without anxious distress. Those with anxious distress started out more ill but still improved, and patient-rated outcomes rose in both groups. Side effects tied to the drug and dropouts for side effects were somewhat more common in the anxious group.
Catalog record
| CREATOR | Hitoshi Sakurai, Keisuke Nomoto, Tomoki Ito, Yasuyuki Matsumoto, Shingo Higa |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 52 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |