Acupoint Selection Patterns and Potential Mechanisms of Acupuncture in Knee Osteoarthritis: A Combined Data Mining and Network Pharmacology Study
Danning Zhang, Shuangxin Yang, Xingxing Lin, Kaixuan Zhang, Baoqiang Dong · 2026
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Description
Danning Zhang and co-authors mine in 2026 hundreds of published acupuncture trials to find the point recipes that knee osteoarthritis care keeps returning to. Needle point choice is traditional and varied, so the team let data speak: frequency counts, association rules, and network analysis over more than five hundred studies and their prescriptions.
A core set of about two dozen points emerged, anchored by classic knee points below and around the joint. Four points stayed central at every arthritis grade. Mild cases leaned on local points near the knee. Worse grades shifted weight toward one anchor point and added more far away points on the limbs. The study then asks how the core recipe might work in the body, intersecting its predicted protein targets with disease genes and mapping the shared network. Grade aware point selection is the practical takeaway for clinicians.
Catalog record
| CREATOR | Danning Zhang, Shuangxin Yang, Xingxing Lin, Kaixuan Zhang, Baoqiang Dong |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 53 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |