Whole‐Brain Monosynaptic Inputs to and Axonal Projections From Posterior Insular Cortex GABAergic Neurons in Mice
Wan‐Qiao Qi, Xin‐Yue Zhang, Wei‐Xiang Ma, Wei‐Min Qu, Jia‐Qi Shi, Zhi‐Li Huang, Yu‐Lan Zhu · 2026
Read Whole‐Brain Monosynaptic Inputs to and Axonal Projections From Posterior Insular Cortex GABAergic Neurons in Mice by Wan‐Qiao Qi, Xin‐Yue Zhang, Wei‐Xiang Ma, Wei‐Min Qu, Jia‐Qi Shi, Zhi‐Li Huang, Yu‐Lan Zhu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13545509.txt.
Description
Wan-Qiao Qi and six co-authors mapped in 2026 the whole-brain wiring of one cell type in a mouse sensory hub. The hub, the posterior insular cortex, blends signals for pain, emotion, and fear memory. Its inhibitory neurons were the focus. Using virus tracers tied to a genetic switch, the team charted which regions send one-step inputs to these cells and where their fibers land.
Forty-five input regions appeared, densest from smell and touch cortex and from two thalamic groups, mostly on the same side. Eighteen output targets appeared, densest in basal ganglia structures and parts of the amygdala. The authors say this input-output map frames how the hub's inhibitory cells may steer behavior, and gives anatomists a reference circuit.
Catalog record
| CREATOR | Wan‐Qiao Qi, Xin‐Yue Zhang, Wei‐Xiang Ma, Wei‐Min Qu, Jia‐Qi Shi, Zhi‐Li Huang, Yu‐Lan Zhu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |