Mixed T-cell chimerism at 3 months predicts late relapse in acute myeloid leukemia after allogeneic stem cell transplantation
Mikael Lisak, Malin Nicklasson, Robert Palmason, Stina Wichert, Anders Eivind Myhre, Trym Døviken, Cecila Isaksson, Kristina Carlson, Johan Törlén, Per-Ola Andersson, Jan-Erik Johansson, Markus Hansson · 2026
Read Mixed T-cell chimerism at 3 months predicts late relapse in acute myeloid leukemia after allogeneic stem cell transplantation by Mikael Lisak, Malin Nicklasson, Robert Palmason, Stina Wichert, Anders Eivind Myhre, Trym Døviken, Cecila Isaksson, Kristina Carlson, Johan Törlén, Per-Ola Andersson, Jan-Erik Johansson, Markus Hansson (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13545257.txt.
Description
Mikael Lisak and co-authors find that a mixed donor-recipient immune picture three months after transplant warns of late relapse in acute myeloid leukemia. Their 2026 study follows 388 patients treated at six Scandinavian centers with donor stem cell transplants. Relapse is the main cause of failure after transplant, yet who relapses late has been hard to foresee.
Among patients alive and relapse-free at one year, those whose T cells were still partly their own at three months relapsed more over five years than those fully donor. Their relapse-free survival was also worse. Leftover disease before transplant, by contrast, mainly warned of early relapse. The authors offer the three-month check as a simple risk flag.
Catalog record
| CREATOR | Mikael Lisak, Malin Nicklasson, Robert Palmason, Stina Wichert, Anders Eivind Myhre, Trym Døviken, Cecila Isaksson, Kristina Carlson, Johan Törlén, Per-Ola Andersson, Jan-Erik Johansson, Markus Hansson |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |