Effect of human urinary microenvironment and fluid flow on antibiotic and phage therapy efficacy against uropathogenic Escherichia coli
Ramon Garcia Maset, Aaron Crowther, Victoria Chu, Davide De Grandi, Rizka O A Jariah, Jenny Yoon, Dalia Blumgart, Marloes A E Hodek, Francesca Torelli, Nicholas Yuen, Benjamin O Murray, Katie L Holden, James Bancroft, Laia Pasquina-Lemonche, Sara N H Alghamd, Andrew D Millard, Gareth LuTheryn, Melis · 2026
Read Effect of human urinary microenvironment and fluid flow on antibiotic and phage therapy efficacy against uropathogenic Escherichia coli by Ramon Garcia Maset, Aaron Crowther, Victoria Chu, Davide De Grandi, Rizka O A Jariah, Jenny Yoon, Dalia Blumgart, Marloes A E Hodek, Francesca Torelli, Nicholas Yuen, Benjamin O Murray, Katie L Holden, James Bancroft, Laia Pasquina-Lemonche, Sara N H Alghamd, Andrew D Millard, Gareth LuTheryn, Melis (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13545223.txt.
Description
Ramon Garcia Maset and co-authors report a microbiology study, published in 2026, testing bladder infection treatments inside a model that mimics the human urinary tract. Standard lab tests often fail to predict whether a urinary infection will clear, because real infections unfold in urine, on living tissue, and under flow. The team combined human urine, a three dimensional bladder tissue model, and a flow platform that washes the tissue.
A standard antibiotic looked strongest in simple tests yet failed to wipe out infection in the tissue model. A virus cocktail that infects bacteria attacked hidden bacterial communities and kept tissue alive, while provoking immune signals. Pairing both cleared free bacteria and shrank communities further under still conditions, showing why realistic models matter before trials.
Catalog record
| CREATOR | Ramon Garcia Maset, Aaron Crowther, Victoria Chu, Davide De Grandi, Rizka O A Jariah, Jenny Yoon, Dalia Blumgart, Marloes A E Hodek, Francesca Torelli, Nicholas Yuen, Benjamin O Murray, Katie L Holden, James Bancroft, Laia Pasquina-Lemonche, Sara N H Alghamd, Andrew D Millard, Gareth LuTheryn, Melis |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 107 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |