CAR T-cell therapy as a definitive consolidation for older adults with B-ALL in first complete remission∗†
Ibrahim Aldoss, Lior Goldberg, Jianying Zhang, Andrew Artz, Mary C Clark, Min Guan, Ruby Espinosa, Thiruvaimozhi Abimannan, Jiaqi Wu, Bryan Garcia, Eric R Haas, Khyatiben V Pathak, Brooke Lovell, Patrick Pirrotte, Vaibhav Agrawal, Neguine Sanani, Stephanie Kasten, Dileshni Tilakawardane, Jamie R Wag · 2026
Read CAR T-cell therapy as a definitive consolidation for older adults with B-ALL in first complete remission∗† by Ibrahim Aldoss, Lior Goldberg, Jianying Zhang, Andrew Artz, Mary C Clark, Min Guan, Ruby Espinosa, Thiruvaimozhi Abimannan, Jiaqi Wu, Bryan Garcia, Eric R Haas, Khyatiben V Pathak, Brooke Lovell, Patrick Pirrotte, Vaibhav Agrawal, Neguine Sanani, Stephanie Kasten, Dileshni Tilakawardane, Jamie R Wag (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13544187.txt.
Description
Older adults with B-cell acute lymphoblastic leukemia face harsh chemotherapy, so a gentler consolidation would be welcome. The authors report a phase 1 study of CD19 CAR T cells as definitive consolidation for patients aged 55 and over in first complete remission. Eighteen patients, median age 64 and all measurable-residual-disease negative, received lymphodepletion then memory-enriched CAR T cells.
There were no dose-limiting toxicities, no grade 2 or worse cytokine release syndrome, and no neurotoxicity syndrome at all. Estimated 18-month event-free survival was 84 percent and overall survival 100 percent. The cells expanded in blood and spinal fluid even with no measurable disease. Compared with samples from relapsed patients, the remission patients' blood and cell products were far less inflammatory. The authors back wider study of early CAR T use in this leukemia.
Catalog record
| CREATOR | Ibrahim Aldoss, Lior Goldberg, Jianying Zhang, Andrew Artz, Mary C Clark, Min Guan, Ruby Espinosa, Thiruvaimozhi Abimannan, Jiaqi Wu, Bryan Garcia, Eric R Haas, Khyatiben V Pathak, Brooke Lovell, Patrick Pirrotte, Vaibhav Agrawal, Neguine Sanani, Stephanie Kasten, Dileshni Tilakawardane, Jamie R Wag |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |