On the Robustness of Preoperative Intranasal Dexmedetomidine for Postoperative Delirium Prevention: Methodological Considerations [Letter]
Hongyu Gai, Minggan Bao, Bo Chen · 2026
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Description
A trial found that a sedative sniffed before surgery cut delirium in older joint-replacement patients, crediting longer sleep for much of the effect. Hongyu Gai, Minggan Bao, and Bo Chen write in 2026 to probe that claim's strength. The trial saw fewer delirium events than planned for, thirty-six in all, so its headline result may rest on a fragile count of cases.
They also fault the sleep mediation analysis for ignoring confounders, noting its effect range even crosses one hundred percent. And two hours of safety watching, they warn, could miss the drug's delayed blood-pressure dips in the small hours. They ask the authors to answer with fuller models.
Catalog record
| CREATOR | Hongyu Gai, Minggan Bao, Bo Chen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 5 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |