Short-chain fatty acids act as metabolic and epigenetic regulators in CAR T cell therapy
Ming-Yang Ma, Chen-Xin Zhou, Xin-Yu Shi, Jian-Min Zhu, Cai-Wen Duan · 2026
Read Short-chain fatty acids act as metabolic and epigenetic regulators in CAR T cell therapy by Ming-Yang Ma, Chen-Xin Zhou, Xin-Yu Shi, Jian-Min Zhu, Cai-Wen Duan (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13543960.txt.
Description
Chimeric antigen receptor (CAR) T cell therapy has transformed the treatment of hematologic malignancies, but its efficacy in solid tumors remains constrained by poor infiltration, metabolic stress, and limited persistence. Short-chain fatty acids (SCFAs), particularly butyrate and pentanoate, offer a way to influence CAR T metabolism and chromatin state during manufacturing.
Catalog record
| CREATOR | Ming-Yang Ma, Chen-Xin Zhou, Xin-Yu Shi, Jian-Min Zhu, Cai-Wen Duan |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |