SNX-BAR proteins 5 and 6 are required for NCOA7-AS antiviral activity against influenza A virus
Mary Arnaud-Arnould, Antoine Rebendenne, Marine Tauziet, Serge Urbach, Khadija El Koulali, Emiliano P Ricci, Mélanie Wencker, Olivier Moncorgé, Mickaël Blaise, Caroline Goujon · 2026
Read SNX-BAR proteins 5 and 6 are required for NCOA7-AS antiviral activity against influenza A virus by Mary Arnaud-Arnould, Antoine Rebendenne, Marine Tauziet, Serge Urbach, Khadija El Koulali, Emiliano P Ricci, Mélanie Wencker, Olivier Moncorgé, Mickaël Blaise, Caroline Goujon (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13543948.txt.
Description
Mary Arnaud-Arnould and colleagues published a 2026 study of the cellular partners an interferon-induced antiviral protein needs to block influenza A virus. The protein, NCOA7-AS, stops the virus fusing out of the cell's sorting compartments, apparently by making them more acidic through the proton pump it touches. Mass spectrometry of its binding partners confirmed the pump connection and revealed the sorting nexins, proteins that ferry cargo from endosomes back toward the cell's shipping hub.
A mutation breaking the pump interaction destroyed the antiviral effect, proving that contact essential. Two nexins, SNX5 and SNX6, bound the protein directly and were likewise required for protection. Crystal structures showed the antiviral protein presents a motif resembling the nexins' normal cargo, and pinpointed the exact residues doing the gripping. Host trafficking machinery, the authors show, is conscripted into antiviral defence.
Catalog record
| CREATOR | Mary Arnaud-Arnould, Antoine Rebendenne, Marine Tauziet, Serge Urbach, Khadija El Koulali, Emiliano P Ricci, Mélanie Wencker, Olivier Moncorgé, Mickaël Blaise, Caroline Goujon |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 60 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |