Improved outcomes with TKI maintenance after brexucabtagene autoleucel in Philadelphia chromosome ALL
Tamer Othman, Gregory W Roloff, Katharine Miller, Amy Zhang, Katherine C Sutherland, Rawan Faramand, LaQuisa C Hill, Ibrahim N Muhsen, Nikeshan Jeyakumar, Abdullah Ladha, Josh Sasine, Chenyu Lin, Noam E Kopmar, Stephanie B Tsai, Timothy E O'Connor, Talal Hilal, Melhem M Solh, Caitlin Guzowski, Virgi · 2026
Read Improved outcomes with TKI maintenance after brexucabtagene autoleucel in Philadelphia chromosome ALL by Tamer Othman, Gregory W Roloff, Katharine Miller, Amy Zhang, Katherine C Sutherland, Rawan Faramand, LaQuisa C Hill, Ibrahim N Muhsen, Nikeshan Jeyakumar, Abdullah Ladha, Josh Sasine, Chenyu Lin, Noam E Kopmar, Stephanie B Tsai, Timothy E O'Connor, Talal Hilal, Melhem M Solh, Caitlin Guzowski, Virgi (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13543946.txt.
Description
Tamer Othman and a large team study whether a targeted drug after cell therapy helps adults with a hard leukemia, in a paper dated twenty twenty-six. The leukemia carries the Philadelphia chromosome change and had returned or resisted past care. A cell therapy called brexu-cel often clears it fully, yet relapse stays common. The team followed fifty-one patients across nineteen United States centers who had cleared the disease.
Twenty patients then took a maintenance drug from the TKI family, while thirty-one did not. Maintenance cut the one-year relapse rate sharply and lengthened the time free of disease growth. A trend toward longer survival also appeared. The authors back maintenance as a way to hold remissions.
Catalog record
| CREATOR | Tamer Othman, Gregory W Roloff, Katharine Miller, Amy Zhang, Katherine C Sutherland, Rawan Faramand, LaQuisa C Hill, Ibrahim N Muhsen, Nikeshan Jeyakumar, Abdullah Ladha, Josh Sasine, Chenyu Lin, Noam E Kopmar, Stephanie B Tsai, Timothy E O'Connor, Talal Hilal, Melhem M Solh, Caitlin Guzowski, Virgi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 20 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |