Plasticity in a bacterial global regulatory switch that drives a shift in antibiotic resistance and virulence
Annapaula Correia, Emma J Manners, Benjamin A Evans, Jacob G Malone, Justin O’Grady, Eleni Mavrogiorgou, Sergio Arminu, Manuela Usai, Dixita Naik, Stuart McMillan, Gemma L Kay, Claire Hill, Padhmanand Sudhakar, Emma Meader, Katarzyna Schmidt, Tamas Korcsmaros, Andrew P Desbois, Lisa Crossman, John W · 2026
Read Plasticity in a bacterial global regulatory switch that drives a shift in antibiotic resistance and virulence by Annapaula Correia, Emma J Manners, Benjamin A Evans, Jacob G Malone, Justin O’Grady, Eleni Mavrogiorgou, Sergio Arminu, Manuela Usai, Dixita Naik, Stuart McMillan, Gemma L Kay, Claire Hill, Padhmanand Sudhakar, Emma Meader, Katarzyna Schmidt, Tamas Korcsmaros, Andrew P Desbois, Lisa Crossman, John W (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13543918.txt.
Description
Annapaula Correia and co-authors study a gene switch in a common germ that can change how the germ resists drugs and how harmful it is, in work from 2026. The germ often infects people in hospitals and can be hard to treat. The switch is a protein named MexT, and lab strains of the germ differ in whether it is active.
When the switch was active, the activity of about nine hundred genes shifted. Tests also showed changes in growth, drug response, and harm traits. Adding drug resistance to fresh samples from patients led to changes in the same gene once drug pressure was lifted. The team argues this helps explain why lab strains can behave so unlike real ones.
Catalog record
| CREATOR | Annapaula Correia, Emma J Manners, Benjamin A Evans, Jacob G Malone, Justin O’Grady, Eleni Mavrogiorgou, Sergio Arminu, Manuela Usai, Dixita Naik, Stuart McMillan, Gemma L Kay, Claire Hill, Padhmanand Sudhakar, Emma Meader, Katarzyna Schmidt, Tamas Korcsmaros, Andrew P Desbois, Lisa Crossman, John W |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 63 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |