Protocol for 3D digital dynamic histomorphometry of mouse bone via time-lapse registration of serial microCT scans
Quentin A. Meslier, Nicole Migotsky, Syeda N. Lamia, Erica L. Scheller, Matthew J. Silva · 2026
Read Protocol for 3D digital dynamic histomorphometry of mouse bone via time-lapse registration of serial microCT scans by Quentin A. Meslier, Nicole Migotsky, Syeda N. Lamia, Erica L. Scheller, Matthew J. Silva (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13543904.txt.
Description
Meslier and four co-authors present a 2026 protocol for tracking how mouse bone grows and shrinks over time in three dimensions. Repeated microCT scans of living mice can show bone change, but the scans must be aligned precisely before change can be measured. Their method aligns scans taken before and after an intervention through a simple drag-and-click workflow that needs no special training.
Once aligned, the scans show where bone formed, where it was resorbed, and where it stayed quiet. The method maps these changes on inner and outer surfaces of the shin bone, across several regions. It works on cortical and spongy bone alike. The authors offer it as a non-destructive partner to the classic dye-based method, which needs tissue samples.
Catalog record
| CREATOR | Quentin A. Meslier, Nicole Migotsky, Syeda N. Lamia, Erica L. Scheller, Matthew J. Silva |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 125 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |