Bacteroidesacidifaciens Attenuates Concanavalin A–Induced Liver Injury by Remodeling Bile Acids to Suppress CD95-Mediated Hepatocyte Apoptosis via the TGR5–FOSL1 Pathway
Xiang Zhang, Cheng Zhang, Yi Zhou, Yu Han, Yawei Wang, Hesuiyuan Wang, Mengyan Yang, Qinhan Wu, Feng Bai, Fanfan Qu, Jianbin Ji, Hongru Zhang, Zhenglu Wang, Yuebing Wang, Haijin Xu, Zhenghua Zhou, Mingqiang Qiao, Zhenzhou Wu · 2026
Read Bacteroidesacidifaciens Attenuates Concanavalin A–Induced Liver Injury by Remodeling Bile Acids to Suppress CD95-Mediated Hepatocyte Apoptosis via the TGR5–FOSL1 Pathway by Xiang Zhang, Cheng Zhang, Yi Zhou, Yu Han, Yawei Wang, Hesuiyuan Wang, Mengyan Yang, Qinhan Wu, Feng Bai, Fanfan Qu, Jianbin Ji, Hongru Zhang, Zhenglu Wang, Yuebing Wang, Haijin Xu, Zhenghua Zhou, Mingqiang Qiao, Zhenzhou Wu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13543890.txt.
Description
Xiang Zhang and colleagues published a 2026 study of how a gut bacterium, Bacteroides acidifaciens, protects the liver from immune-driven injury by reshaping bile acids. Mice were fed the bacterium and then challenged with concanavalin A, a standard trigger of liver hepatitis. Bile acid profiles in the liver shifted, and one acid, glycocholic acid, was pursued through cell experiments using receptor blockers and gene deletion to find its route of action.
The bacterium raised hepatic glycocholic acid, which lowered the death receptor CD95 on liver cells at both the gene and surface-protein levels. Blocking or deleting its receptor, TGR5, abolished that protection, and a transcription factor called FOSL1 carried the signal onward. Mice given the acid in drinking water for thirty-five days resisted the hepatitis with less cell death. A gut microbe's bile-acid messenger, the authors show, can disarm a liver death pathway.
Catalog record
| CREATOR | Xiang Zhang, Cheng Zhang, Yi Zhou, Yu Han, Yawei Wang, Hesuiyuan Wang, Mengyan Yang, Qinhan Wu, Feng Bai, Fanfan Qu, Jianbin Ji, Hongru Zhang, Zhenglu Wang, Yuebing Wang, Haijin Xu, Zhenghua Zhou, Mingqiang Qiao, Zhenzhou Wu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 65893 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |