Microfluidic-engineered glucose-responsive microparticle depot for smart insulin delivery
Zhihan Li, YanWen Zhang, Chuanpin Chen · 2026
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Description
Zhihan Li, Yanwen Zhang, and Chuanpin Chen build a tiny insulin depot that releases more drug when sugar runs high. Diabetes care still leans on fixed doses and finger checks. A self-regulating depot could smooth the daily swings.
Their microspheres are made in a microfluidic chip, which keeps every sphere the same size. An enzyme inside senses glucose and triggers release. The shell blends a standard medical plastic with a sugar-derived, acid-sensitive partner. Uniform spheres mean uniform dosing, a manufacturing point as much as a medical one. Remaining hurdles include body compatibility and scale-up. The study shows a working design, not yet a therapy.
Catalog record
| CREATOR | Zhihan Li, YanWen Zhang, Chuanpin Chen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 60 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |