Monocyte Transcriptional Reprogramming Explains Refractory In-Stent Restenosis
Joseph Bednarek, Juan Ibla, Edward B. Thorp · 2026
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Description
Joseph Bednarek, Juan Ibla, and Edward B. Thorp comment in 2026 on work by Yu and co-authors about stents that keep failing. The problem is repeat narrowing inside a heart stent that does not respond to standard drugs. The comment links this pattern to a local vessel disease with no body-wide signs.
Single-cell tests in the study under review mapped immune cells in heart blood and found one switch, called AP-1, at fault. When active, the switch makes blood cells pour out signals that keep the vessel wall inflamed. The piece frames this as a new target for care.
Catalog record
| CREATOR | Joseph Bednarek, Juan Ibla, Edward B. Thorp |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 11 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |