Bio‐guided fractionation of (9Z )‐5,8,11‐trihydroxyoctadec‐9‐enoic acid from Abelmoschus sagittifolius root as a potent α‐glucosidase inhibitor: An integrated in vitro and in silico study
Nguyen Phuong Mai, Nguyen Van Quan, Nguyen Dang Duc, Tran Dang Xuan · 2026
Read Bio‐guided fractionation of (9Z )‐5,8,11‐trihydroxyoctadec‐9‐enoic acid from Abelmoschus sagittifolius root as a potent α‐glucosidase inhibitor: An integrated in vitro and in silico study by Nguyen Phuong Mai, Nguyen Van Quan, Nguyen Dang Duc, Tran Dang Xuan (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13543704.txt.
Description
In 2026, Nguyen Phuong Mai and colleagues published a study of a fatty acid from the roots of Abelmoschus sagittifolius, a medicinal plant. They tested it as a blocker of alpha-glucosidase, the gut enzyme that releases glucose from starch and a target of diabetes drugs. Guided by activity, the team isolated a fraction rich in the compound, tested it against the enzyme, modelled its binding on a computer, and screened its predicted safety.
The fraction inhibited the enzyme at a concentration more than a hundred times lower than the standard drug acarbose needed. Kinetics showed mixed inhibition, gripping the free enzyme most tightly, and docking placed the molecule snugly in the enzyme's active pocket. Simulated digestion reduced how much would be absorbed, a practical caveat, while toxicity prediction judged the compound non-toxic. The authors present it as a functional-food lead needing animal and clinical confirmation.
Catalog record
| CREATOR | Nguyen Phuong Mai, Nguyen Van Quan, Nguyen Dang Duc, Tran Dang Xuan |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42993 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |