Immunopathogenesis of neuropsychiatric systemic lupus erythematosus: current insights into inflammatory and thrombotic pathways
Igor Adamski, Anna Wardowska · 2026
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Description
Igor Adamski and Anna Wardowska published a 2026 review of how lupus attacks the nervous system, producing neuropsychiatric symptoms from mood change to seizures and stroke-like events. This manifestation is among the disease's most severe and least understood. The review organises evidence around two overlapping routes: an autoimmune-inflammatory route, where immune attack inflames the brain directly, and a clotting-ischaemic route, where vessels are injured and blocked.
Both routes converge on a leaky blood-brain barrier, immune cells entering brain tissue, and overactivated microglia, the brain's resident immune cells. The authors weigh the case for neutrophil traps, complement, interferon signalling, and self-reactive lymphocytes, separating what human studies show from what animal and cell models merely suggest. Better biomarkers and mechanism-matched treatments are the field's pressing needs, they conclude.
Catalog record
| CREATOR | Igor Adamski, Anna Wardowska |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 80639 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |