Curative treatment is feasible for recurrent hepatocellular carcinoma regardless of recurrence pattern after hepatitis C virus eradication with interferon-free direct-acting antiviral therapy
Satoru Hagiwara, Takuya Matsubara, Naoya Omaru, Natsuki Okai, Yoriaki Komeda, Kazuomi Ueshima, Yasunori Minami, Masahiro Takita, Masahiro Morita, Hirokazu Chishina, Akihiro Yoshida, Naoshi Nishida, Masatoshi Kudo · 2026
Read Curative treatment is feasible for recurrent hepatocellular carcinoma regardless of recurrence pattern after hepatitis C virus eradication with interferon-free direct-acting antiviral therapy by Satoru Hagiwara, Takuya Matsubara, Naoya Omaru, Natsuki Okai, Yoriaki Komeda, Kazuomi Ueshima, Yasunori Minami, Masahiro Takita, Masahiro Morita, Hirokazu Chishina, Akihiro Yoshida, Naoshi Nishida, Masatoshi Kudo (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13543623.txt.
Description
Satoru Hagiwara and co-authors published a 2026 study of liver cancer returning after hepatitis C was cured with modern direct-acting antivirals. Clearing the virus does not erase cancer risk, especially in patients who already had a tumour. Records of 279 patients who reached sustained viral clearance after 2014 were reviewed for who developed cancer. The twenty-eight recurrences were sorted into spread within the liver, reawakened dormant tumour, or genuinely new cancer.
Thirty-three patients developed cancer after cure, and a prior cancer history was the only independent predictor, multiplying risk about fourteenfold. Recurrences split fairly evenly among the three patterns. Because follow-up was strict, nearly all recurrences were caught at the earliest stages, and curative treatment proved possible in twenty-seven of twenty-eight patients. Whatever form recurrence takes, the authors conclude, vigilant surveillance after viral cure keeps it treatable.
Catalog record
| CREATOR | Satoru Hagiwara, Takuya Matsubara, Naoya Omaru, Natsuki Okai, Yoriaki Komeda, Kazuomi Ueshima, Yasunori Minami, Masahiro Takita, Masahiro Morita, Hirokazu Chishina, Akihiro Yoshida, Naoshi Nishida, Masatoshi Kudo |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 29689 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |