Triple primary synchronous liver cancer in one patient: the first case report and origin speculation through bioinformatics
Zheng Zhou, Shuai Hu, Ting Liu, Danling He, Ting Bu, Lingqiu Mao, Xiyan Zheng, Maoyun Xie, Xianjie Shi · 2026
Read Triple primary synchronous liver cancer in one patient: the first case report and origin speculation through bioinformatics by Zheng Zhou, Shuai Hu, Ting Liu, Danling He, Ting Bu, Lingqiu Mao, Xiyan Zheng, Maoyun Xie, Xianjie Shi (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13543618.txt.
Description
Zheng Zhou and colleagues published a 2026 case report of three different primary liver cancers growing at once in one patient, which they believe is the first such report. A 63-year-old woman with hepatitis B had three neighbouring lesions in one liver segment. Imaging suggested one mixed tumour type with metastases, and the standard tumour marker was normal. After surgical removal, pathology told a stranger story: each lesion was its own cancer type.
Gene testing gave each tumour a distinct mutation profile. Two of them, the mixed tumour and the bile-duct type, shared some mutations and the exact same hepatitis B virus insertion point in their DNA, evidence they sprang from one ancestral clone. The third cancer had no virus insertion and a separate origin. Multiple primaries in one organ, the case shows, can hide behind an imaging diagnosis of spread.
Catalog record
| CREATOR | Zheng Zhou, Shuai Hu, Ting Liu, Danling He, Ting Bu, Lingqiu Mao, Xiyan Zheng, Maoyun Xie, Xianjie Shi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34715 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |