Chemical profiling and evaluation of in vitro antibacterial and antibiotic synergistic activities of Cleistanthus bracteosus Jabl. from Malaysian rainforests
Mackingsley Kushan Dassanayake, Teng-Jin Khoo, Chien Hwa Chong, Christophe Wiart, Omar Ashraf Elfar, Rachael Symonds, Mohammed Tahir Ansari · 2026
Read Chemical profiling and evaluation of in vitro antibacterial and antibiotic synergistic activities of Cleistanthus bracteosus Jabl. from Malaysian rainforests by Mackingsley Kushan Dassanayake, Teng-Jin Khoo, Chien Hwa Chong, Christophe Wiart, Omar Ashraf Elfar, Rachael Symonds, Mohammed Tahir Ansari (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13543593.txt.
Description
Mackingsley Kushan Dassanayake's team studied Cleistanthus bracteosus in 2026, a tree of Malaysian rainforests, as a source of germ-fighting compounds and antibiotic helpers. Extracts of bark, stem, and wood were made in three solvents and tested against seven harmful germs, alone and paired with standard antibiotics. The most active extract was split into parts and its makeup charted, and treated bacteria were viewed by electron microscopy.
The chloroform stem extract worked best alone, chiefly against Bacillus cereus. Pairings shone brighter: wood extract with ampicillin strongly blocked the stubborn Acinetobacter baumannii, and a clavulanate partner gave wide clear zones against E. coli and Salmonella typhi. Lab analysis found twenty bioactive plant compounds in the chloroform extracts, among known groups such as flavonoids and tannins. Rainforest plants, the authors argue, may rescue failing antibiotics rather than replace them.
Catalog record
| CREATOR | Mackingsley Kushan Dassanayake, Teng-Jin Khoo, Chien Hwa Chong, Christophe Wiart, Omar Ashraf Elfar, Rachael Symonds, Mohammed Tahir Ansari |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 95074 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |