A third-generation, high-affinity biparatopic anti-tau antibody inhibits intracellular tau aggregation seeded by Alzheimer’s brain extracts
Eric Hatterer, Lucile Broyer, Sara Pecoraro, Fabien Cusin, Naz Simsek, John J Breve, Mathieu Clavel, Kevin L. Batenburg, Bart Klein, Thuur Zuidweg, Kristin Piché, Jeremie Bourguignon, Margot Bonnet-Gamard, Pauline Malinge, Franck Gueneau, Valery Moine, Nadia Anceriz, Krzysztof Masternak, Nicolas Fis · 2026
Read A third-generation, high-affinity biparatopic anti-tau antibody inhibits intracellular tau aggregation seeded by Alzheimer’s brain extracts by Eric Hatterer, Lucile Broyer, Sara Pecoraro, Fabien Cusin, Naz Simsek, John J Breve, Mathieu Clavel, Kevin L. Batenburg, Bart Klein, Thuur Zuidweg, Kristin Piché, Jeremie Bourguignon, Margot Bonnet-Gamard, Pauline Malinge, Franck Gueneau, Valery Moine, Nadia Anceriz, Krzysztof Masternak, Nicolas Fis (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13543575.txt.
Description
Eric Hatterer and co-authors test a new antibody built to bind a brain plaque protein at two spots. The study appeared in 2026. Past plaque shots showed hope but needed high doses. The new build aims for tight binds, strong clump blocks, and a long life in blood.
The antibody grips two zones of the protein at once. Tests used lab-made protein and, with more weight, extracts from sick human brains. It caught a broad spread of bad protein forms at low dose. It blocked cell clumping sparked by the extracts past bench marks. Tweaks to its tail sped cell recycle of the drug, which may stretch dose gaps.
Catalog record
| CREATOR | Eric Hatterer, Lucile Broyer, Sara Pecoraro, Fabien Cusin, Naz Simsek, John J Breve, Mathieu Clavel, Kevin L. Batenburg, Bart Klein, Thuur Zuidweg, Kristin Piché, Jeremie Bourguignon, Margot Bonnet-Gamard, Pauline Malinge, Franck Gueneau, Valery Moine, Nadia Anceriz, Krzysztof Masternak, Nicolas Fis |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 78 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |