Alpelisib enhances cisplatin mediated cytotoxicity in non-mutated, PIK3CA-dependent high-grade serous ovarian cancer
Megha Mehrotra, Sourav Chakraborty, Elveera Saldanha, Diksha Joshi, Ajit Dhadve, Asmita Sakpal, Pratik Chandrani, Amita Maheshwari, Santosh Menon, Jaya Ghosh, Sudeep Gupta, Pritha Ray · 2026
Read Alpelisib enhances cisplatin mediated cytotoxicity in non-mutated, PIK3CA-dependent high-grade serous ovarian cancer by Megha Mehrotra, Sourav Chakraborty, Elveera Saldanha, Diksha Joshi, Ajit Dhadve, Asmita Sakpal, Pratik Chandrani, Amita Maheshwari, Santosh Menon, Jaya Ghosh, Sudeep Gupta, Pritha Ray (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13543539.txt.
Description
In a 2026 study, Megha Mehrotra and colleagues tested whether the drug alpelisib, which blocks the growth-signalling protein PI3K, can make cisplatin chemotherapy work better in high-grade serous ovarian cancer. This cancer is usually found late and often becomes platinum-resistant. The team used tumour cells grown from patients' abdominal fluid, established cell lines, and patient-derived tumours in mice, and profiled mutations to learn which cancers respond.
The combination killed cancer cells in about a third of patient samples, and most responders carried extra copies of the PIK3CA gene even without mutations in it. Certain mutant forms of the p53 protein proved to switch PIK3CA production up after cisplatin exposure, handing the combination its opening. In mice, the pairing halted tumours carrying one such p53 mutant but not tumours with normal p53. Mutation type, not just the target gene, may therefore decide who benefits.
Catalog record
| CREATOR | Megha Mehrotra, Sourav Chakraborty, Elveera Saldanha, Diksha Joshi, Ajit Dhadve, Asmita Sakpal, Pratik Chandrani, Amita Maheshwari, Santosh Menon, Jaya Ghosh, Sudeep Gupta, Pritha Ray |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 87804 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |