Metal Ions in Longgu (Fossilized Bone) as a Natural Synergistic Network for Multi‐Target Therapy in Psychiatric Disorders

Sun Xiujia, Li Zhan Hua, Gao Yuanze, Liu Jing, Li Li, Zhang Chao, Kumar Ganesan, Jianping Chen · 2026

Read Metal Ions in Longgu (Fossilized Bone) as a Natural Synergistic Network for Multi‐Target Therapy in Psychiatric Disorders by Sun Xiujia, Li Zhan Hua, Gao Yuanze, Liu Jing, Li Li, Zhang Chao, Kumar Ganesan, Jianping Chen (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13543331.txt.

Description

Longgu, fossilized bone, has calmed anxious and sleepless patients in Chinese medicine for centuries. Sun Xiujia and co-authors review a modern explanation: its metal ions work as a team. They gather chemical analyses, studies of single ions, and clinical trials of formulas containing the mineral.

Calcium and magnesium steady neuron firing. Zinc tunes neurotransmission and supports a growth factor tied to brain plasticity. Zinc and manganese together help run the gut-brain axis. Trials show the formulas ease depression, anxiety, and insomnia, especially combined, and boost standard antidepressants. The 2026 review offers Longgu as a model for multi-target psychiatric drug design.

Catalog record

CREATORSun Xiujia, Li Zhan Hua, Gao Yuanze, Liu Jing, Li Li, Zhang Chao, Kumar Ganesan, Jianping Chen
YEAR2026
COLLECTIONPAPERS
FORMATTXT
FILE SIZE85 KB
VERSION1.0
LICENSECC BY 4.0
RIGHTSCC BY
SOURCEEurope PMC

Source: https://europepmc.org/articles/PMC13543331

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