Organelle Crosstalk and Metabolic Reprogramming in Idiopathic Pulmonary Fibrosis: Mechanisms and Therapeutic Implications
Yining Zhang, Ling Teng, Limin Gong, Yuandong Fu, Minyi Qian · 2026
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Description
Yining Zhang and co-authors review how cell organelles fail and talk to each other in idiopathic pulmonary fibrosis, a fatal lung scarring disease of unknown cause. Scar tissue builds up in the lung and slowly wrecks its shape, ending in breathing failure. Faults in many cell types drive the process.
The 2026 review covers four organelles: mitochondria, the endoplasmic reticulum, lysosomes, and peroxisomes. It also covers shifts in how lung cells burn fuel. The authors trace how faults in one part spread through the network and push scarring on. Their goal is to find key nodes where a drug might break the loop and slow the disease.
Catalog record
| CREATOR | Yining Zhang, Ling Teng, Limin Gong, Yuandong Fu, Minyi Qian |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 92 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |